Rabbit Secondary Antibodies
Jackson Immuno Research Labs Peroxidase-AffiniPure Rabbit Anti-Human Serum IgA α Chain Specific
Peroxidase-AffiniPure Rabbit Anti-Human Serum IgA α Chain Specific
ABclonal Technology 647 Rabbit anti-Human CD46
The protein encoded by this gene is a type I membrane protein and is a regulatory part of the complement system The encoded protein has cofactor activity for inactivation of complement components C3b and C4b by serum factor I which protects the host cell from damage by complement In addition the encoded protein can act as a receptor for the Edmonston strain of measles virus human herpesvirus-6 and type IV pili of pathogenic Neisseria Finally the protein encoded by this gene may be involved in the fusion of the spermatozoa with the oocyte during fertilization Mutations at this locus have been associated with susceptibility to hemolytic uremic syndrome Alternatively spliced transcript variants encoding different isoforms have been described
Cayman Chemical AMD 3465hydrobromIde 25mg
Blocks the cell surface binding of the CXCR4 ligand CXCL12 (IC50 = 18 nM), inhibits calcium mobilization (IC50 = 4 nM), and (at 6,250 nM) completely blocks chemotaxis of SupT1 cells; active against various HIV strains (IC50s = 6-12 nM)
ABclonal Technology 488 Rabbit anti-Human GP6/GPVI
This gene encodes a platelet membrane glycoprotein of the immunoglobulin superfamily The encoded protein is a receptor for collagen and plays a critical role in collagen-induced platelet aggregation and thrombus formation The encoded protein forms a complex with the Fc receptor gamma-chain that initiates the platelet activation signaling cascade upon collagen binding Mutations in this gene are a cause of platelet-type bleeding disorder-11 (BDPLT11) Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene
ABclonal Technology 647 Rabbit anti-Human PTH1R
The protein encoded by this gene is a member of the G-protein coupled receptor family 2 This protein is a receptor for parathyroid hormone (PTH) and for parathyroid hormone-like hormone (PTHLH) The activity of this receptor is mediated by G proteins which activate adenylyl cyclase and also a phosphatidylinositol-calcium second messenger system Defects in this receptor are known to be the cause of Jansen s metaphyseal chondrodysplasia (JMC) chondrodysplasia Blomstrand type (BOCD) as well as enchodromatosis Two transcript variants encoding the same protein have been found for this gene
ABclonal Technology 488 Rabbit anti-Human Siglec-8
Sialic acid-binding immunoglobulin (Ig)-like lectins or SIGLECs (e g CD33 (MIM 159590)) are a family of type 1 transmembrane proteins each having a unique expression pattern mostly in hemopoietic cells SIGLEC8 is a member of the CD33-like subgroup of SIGLECs which are localized to 19q13 3-q13 4 and have 2 conserved cytoplasmic tyrosine-based motifs an immunoreceptor tyrosine-based inhibitory motif or ITIM (see MIM 604964) and a motif homologous to one identified in signaling lymphocyte activation molecule (SLAM MIM 603492) that mediates an association with SLAM-associated protein (SAP MIM 300490) (summarized by Foussias et al 2000 [PubMed 11095983])
ABclonal Technology 647 Rabbit anti-Human CD142
This gene encodes coagulation factor III a cell surface glycoprotein essential for initiating blood coagulation It acts as a high-affinity receptor for factor VII forming a complex that triggers protease cascades via limited proteolysis Unlike other coagulation cofactors factor III is fully functional when expressed on cell surfaces such as on monocytes It has extracellular transmembrane and cytoplasmic domains Platelets and monocytes express this factor during procoagulatory and proinflammatory responses Factor III is implicated in HIV-related coagulopathy and is associated with COVID-19 severity and mortality Notably congenital deficiency of this protein has not been observed Multiple transcript variants exist due to alternative splicing
ABclonal Technology 488 Rabbit anti-Human CD59
This gene encodes a cell surface glycoprotein that regulates complement-mediated cell lysis and it is involved in lymphocyte signal transduction This protein is a potent inhibitor of the complement membrane attack complex whereby it binds complement C8 and or C9 during the assembly of this complex thereby inhibiting the incorporation of multiple copies of C9 into the complex which is necessary for osmolytic pore formation This protein also plays a role in signal transduction pathways in the activation of T cells Mutations in this gene cause CD59 deficiency a disease resulting in hemolytic anemia and thrombosis and which causes cerebral infarction Multiple alternatively spliced transcript variants which encode the same protein have been identified for this gene
ABclonal Technology 488 Rabbit anti-Human CD2
The protein encoded by this gene is a surface antigen found on all peripheral blood T-cells The encoded protein interacts with LFA3 (CD58) on antigen presenting cells to optimize immune recognition A locus control region (LCR) has been found in the 3 flanking sequence of this gene
ABclonal Technology 594 Rabbit anti-Human CD142
This gene encodes coagulation factor III a cell surface glycoprotein that initiates blood coagulation cascades by acting as a high-affinity receptor for factor VII The complex formed activates specific proteolysis initiating coagulation Unlike other cofactors factor III is fully functional when expressed on cell surfaces like monocytes It has extracellular transmembrane and cytoplasmic domains Platelets and monocytes express this factor under procoagulatory and proinflammatory conditions and it plays a role in HIV-associated coagulopathy Factor III expression in platelets and monocytes is linked to COVID-19 severity and mortality Congenital deficiency of this factor has not been observed Alternative splicing produces multiple transcript variants
ABclonal Technology PE Rabbit anti-Human CD28 mAb
The protein encoded by this gene is essential for T-cell proliferation and survival cytokine production and T-helper type-2 development Several alternatively spliced transcript variants encoding different isoforms have been found for this gene
ABclonal Technology PE Rabbit anti-Human CD42b mAb
Glycoprotein Ib (GP Ib) is a platelet surface membrane glycoprotein composed of a heterodimer an alpha chain and a beta chain that is linked by disulfide bonds The Gp Ib functions as a receptor for von Willebrand factor (VWF) The complete receptor complex includes noncovalent association of the alpha and beta subunits with platelet glycoprotein IX and platelet glycoprotein V The binding of the GP Ib-IX-V complex to VWF facilitates initial platelet adhesion to vascular subendothelium after vascular injury and also initiates signaling events within the platelet that lead to enhanced platelet activation thrombosis and hemostasis This gene encodes the alpha subunit Mutations in this gene result in Bernard-Soulier syndromes and platelet-type von Willebrand disease The coding region of this gene is known to contain a polymophic variable number tandem repeat (VNTR) domain that is associated with susceptibility to nonarteritic anterior ischemic optic neuropathy
ABclonal Technology 647 Rabbit anti-Human CD6
This gene encodes a protein found on the outer membrane of T-lymphocytes as well as some other immune cells The encoded protein contains three scavenger receptor cysteine-rich (SRCR) domains and a binding site for an activated leukocyte cell adhesion molecule The gene product is important for continuation of T cell activation This gene may be associated with susceptibility to multiple sclerosis (PMID 19525953 21849685) Multiple transcript variants encoding different isoforms have been found for this gene
ABclonal Technology 450 Rabbit anti-Human CD45RA
The protein encoded by this gene is a member of the protein tyrosine phosphatase (PTP) family PTPs are known to be signaling molecules that regulate a variety of cellular processes including cell growth differentiation mitosis and oncogenic transformation This PTP contains an extracellular domain a single transmembrane segment and two tandem intracytoplasmic catalytic domains and thus is classified as a receptor type PTP This PTP has been shown to be an essential regulator of T- and B-cell antigen receptor signaling It functions through either direct interaction with components of the antigen receptor complexes or by activating various Src family kinases required for the antigen receptor signaling This PTP also suppresses JAK kinases and thus functions as a regulator of cytokine receptor signaling Alternatively spliced transcripts variants of this gene which encode distinct isoforms have been reported
ABclonal Technology 594 Rabbit anti-Human IL-5
This gene encodes a cytokine that acts as a growth and differentiation factor for both B cells and eosinophils The encoded cytokine plays a major role in the regulation of eosinophil formation maturation recruitment and survival The increased production of this cytokine may be related to pathogenesis of eosinophil-dependent inflammatory diseases This cytokine functions by binding to its receptor which is a heterodimer whose beta subunit is shared with the receptors for interleukine 3 (IL3) and colony stimulating factor 2 (CSF2 GM-CSF) This gene is located on chromosome 5 within a cytokine gene cluster which includes interleukin 4 (IL4) interleukin 13 (IL13) and CSF2 This gene IL4 and IL13 may be regulated coordinately by long-range regulatory elements spread over 120 kilobases on chromosome 5q31